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System for the Preparation of Autologous Platelet-rich Fibrin Matrix (PRFM)

OssiMatrix Platelet-Rich Fibrin Matrix (PRFM)

The OssiMatrix System is designed for the safe and rapid preparation of Platelet-rich Fibrin Matrix (PRFM) from a small sample of blood at the patient point of care. Many PRP systems require operator skill, have varying results and have extensive contamination with red blood cells and white blood cells. OssiMatrix removes virtually all contaminating cells and is independent of operator technique. PRP is converted to PRFM through a controlled process, creating a scaffold that serves to protect and preserve platelets. Think of OssiMatrixPRFM as the next generation PRP.

What is Platelet-Rich Plasma (PRP)

PRP is a solution of plasma and platelets where the platelet concentration is higher than whole blood.
Optimal platelet concentration is 2-3X greater than whole blood.
Definition of PRP dues NOT include red blood cells (RBC) or white blood cells (WBC).
RBC and WBC should be removed as much as possible from PRP preparation.
RP kits that tout high platelet concentrations often have contaminating RBCs or WBCs which have inflammatory and catabolic effects causing opposite effect of desired outcome.
Pink or red PRP has RBC contamination.
The ideal PRP solution will be a golden, straw-like color.

Platelet-Rich Fibrin Gel (PRFG)

Features

"Golden" Visual Guide to Quality
Purest PRP/PRFM
Closed-System
Secondary Proprietary Step
Converts PRP to PRFG

Fibrin Matrix Scaffold is Key!

Fibrin Matrix Scaffold is KEY!
Calcium chloride allows for controlled fibrin polymerization
Scaffold is a biologic connector
Platelets are localized and viable
Sustained growth factor release

PRP VS. PRFM

PRP

Platelets in plasma
Activation is immediate
Alpha granules release growth factors quickly (bolus)
Short-term tissue signaling
Minutes - Hours

PRFM

Platelets in fibrin
CaCl2 binds to Na Citrate 1:1
Clotting cascade resumes (Fibrinogen - Fibrin)
Platelets remain viable with controlled GF release
Hours - Days

The Power of Blood

As part of the body's capacity to heal itself, platelets and other components in human blood migrate to a site of injury. Platelets are known to release a variety of factors that respond to tissue injury, where they initiate and promote healing. By concentrating platelets at the site of injury, physicians have the potential to enhance the body's natural capacity for healing.

1. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT, Autologous platelets as a source of proteins for healing and tissue regeneration, Thromb Haemost, 2004; 91(1):4-15

2. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma. Am J Sports Med. 2009; 37:2259-2272.

The OssiMatrix system is designed to be used for the safe and rapid preparation of autologous platelet-rich-plasma (PRP) from a small sample of blood at the patient point of care. The PRP is mixed with autograft and/or allograft bone prior to application to a bony defect for improving handling characteristics.

Platelets Release Growth Factors

Sustained Growth Factor Release

The Ossumatrix Process

Optimal Platelet Concentration

In Vitro, Animal and Human Studies Physiologic Range is Better Than Pharmacologic Range [Wound Healing, Bone, Spinal Cord Injury]

Those methods with lower concentrations of platelets - 1 to 3 times baseline - showed more robust healing rates than those with higher concentrations 3 to 8 times baseline."

Rappl LM et al., Int Wound J 2011; 8:187-195

"The use of highly concentrated platelet preparations appeared to have an inhibitory influence...reasons could be unwanted inhibitory and cytotoxic effects of growth factors at such high concentrations."

Weibrich G et al., Bone 2004; 34:665-671

"PRP might exert positive effects...in a dose-dependent manner up to a certain level, but adverse effects occur when it is highly concentrated."

Yamaguchi R et al., J Surg Res 2012; 173(2): 258-266

"Optimal results were observed at a platelet concentration of 2.5 X... increased concentrations resulted in a reduction in proliferation and a suboptimal effect on osteoblast function."

Graziani F et al., Olin Oral Imp! Res 2006; 17: 212-219